New biopsy technology detects cancer early

Clinical Sciences
Genetics & Cancer
Project contact
Dr Susan Bodie
Head of Business Development, College of Medicine and Veterinary Medicine
Susan.Bodie@ei.ed.ac.uk

A University of Edinburgh spinout company, BioCaptiva, aims to revolutionise the early diagnosis of difficult-to-detect cancers with a new blood-based biopsy device.

Global market

A recent report shows the global liquid biopsy market growing by a compound annual rate of 33% and projected to be worth more than $6 billion by 2025.

This new technology will be of interest to companies that are developing novel cancer tests limited by current methods of extracting circulating free DNA (cfDNA), where the higher yield achieved by the new device will increase the sensitivity of their detection methods.

BioCollector technology

The spinout has developed a next-generation “liquid biopsy” technology that captures cfDNA from patients’ blood in much greater quantities than is possible through the current standard of a single blood draw, overcoming a significant current limitation of cancer liquid biopsy testing.

Named BioCollector, the device works alongside a standard apheresis machine, filtering cfDNA from the patient’s blood system.

BioCollector is based on a decade of research led by Professor Tim Aitman, Director of the Centre for Genomic and Experimental Medicine, and Professor Mark Bradley of the University’s School of Chemistry.

I’m delighted that after several years of work with colleagues in Edinburgh, we will now progress towards first-in-human trials. BioCollector will provide a step change in the capabilities of liquid biopsy for cancer detection and diagnosis.
We are excited to be moving our device into this market with its huge potential for advances in the care of patients with cancer.

– Professor Tim Aitman, Director of the Centre for Genomic and Experimental Medicine.

Prototype to clinical trials

Prototypes indicate the potential to detect early-stage cancers in patients without the need for surgical biopsy. The BioCollector also promises new approaches for monitoring minimal residual disease and detecting disease recurrence, resulting in better patient outcomes.

With Edinburgh Innovations’ support BioCaptiva has attracted more than £1 million in seed investment from Edinburgh-based investment syndicate Archangels and Scottish Enterprise.

The seed investment will enable BioCaptiva to carry out its first trials to prove its safe use in humans. Should the technology prove successful, BioCaptiva plans to scale up its technology ahead of regulatory clinical trials, scheduled for completion during 2024.

BioCaptiva has very exciting prospects in an important field, based on the leading research of Edinburgh scientists.
The launch of this company, with such solid investment support, promises to improve many people’s lives.

– Dr George Baxter, CEO, Edinburgh Innovations.

If you are interested in this technology or in exploring how Edinburgh Innovations can support innovation in your organisation, please get in touch.

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