Cattle vaccine delivery system
This cattle‐specific vaccine delivery system can readily deliver and express antigens against a range of diseases that affect cattle, offering the potential to provide long term immunity and protection. It can also be used to deliver therapeutic proteins to improve productivity in cattle.
Delivery of therapeutic proteins or other agents to enhance health or productivity of cattle
Reduction in zoonosis to improve human health
Maintain bovine health and maximising bovine productivity
Human health is intimately linked to animal health through the impact of infectious agents on livestock productivity and their potential for zoonosis. A major source of zoonotic infections is cattle which threaten human health through their capacity to transmit bacterial infections including E. coli, Salmonella, Campylobacter, Brucella and Mycobacteria. The use of vaccines is a well-established method of improving animal health and welfare and controlling zoonoses. Although subunit vaccines are considered safer than conventional attenuated or inactivated ones, they have a number of disadvantages including: low levels of immunogenicity; the need to use strong adjuvants; and, typically, a requirement for repeat dosing.
Most cattle are infected with the parasite Trypanosoma theileri (T. theileri); however it causes no ill effects. University of Edinburgh researchers have engineered this parasite to express ‘foreign’ molecules, i.e. immunogenic antigens from diseases that cause severe infections in cattle. When these recombinant parasites are introduced into cattle they express steady sustained levels of antigen in the blood stream producing a sustained immune response over time without the need for vaccine boosters. This system is flexible and can be adapted to deliver multiple antigens against a single host, or cocktails of antigens against a range of different pathogens.
Using versions of T. theileri expressing antigen at different stages of the parasite life cycle we have demonstrated that antigen secreted into the blood stream generates the highest antibody response. Additionally, antigen is expressed at levels safe and sustainable for 12 weeks post inoculation, at levels at least equivalent to those reported for conventional prime-boost immunisation strategy using the same antigen, and antigen-specific antibodies are generated.
- Applicable to any cattle disease, including multiple diseases simultaneously
- Protective immune responses in the absence of adjuvant or booster
- Reduction in zoonoses and improvements to livestock productivity
Mott et al, PLoS Pathogens, Volume 7 (10), e1002340