Engineering Biology and Advanced Therapeutics Innovation Engine

We have one of the largest communities of Mammalian Engineering Biology research globally working closely with a world leading Centre for Regenerative Medicine.

Rapid design-build-test-learn engineering biology cycle

Engineering Biology tools and technologies to drive novel advanced therapeutics

• Drug discovery and development
  • Biosensors with multiple readouts
  • Drug-controllable transcription factors
  • Engineered synthetic stem cell niches
  • Self-assembling cell systems
  • Human Artificial Chromosomes
• Cell and Gene Therapy/Regenerative Medicine
  • Tuneable stem cells using multiple transcription factors
  • Engineered cells for cell replacement (Parkinson’s)
  • Gene therapy viral vectors
  • Theranostics (cells with dual diagnostic/therapeutics modalities)
• Biomanufacturing
  • Safe harbour landing pads for stable plasmid insertion
  • Synthetic transcription factors, chromatin modification and promoters
  • CRISPR-Cas9 gene editing systems
  • State of the art high-throughput clonal cell selection capability

Advanced therapeutics strategic priorities span key disease areas

• Liver
• Cardiovascular
• Oncology
• Lung
• Renal
• Eye
• Neurodevelopmental disorders
• Neurodegenerative disorders

Edinburgh Genome Foundry

• The most advanced fully automated biofoundry worldwide
• High throughput modular assembly of DNA constructs to equip cells with new or improved functions
• Huge capacity to build genetic constructs (1000s a week)
• Combined with Berkeley Lights Beacon optofluidic system (the only one in an academic setting in Europe) provides high throughput analysis and phenotyping

Edinomics

• Provides global metabolome and proteome analyses
• End to end expertise from experimental design to data analysis
• Unique offering of simultaneous metabolite, protein, and lipid extraction to assess multiple molecular classes from one sample
• Rapid metabolomics offering

Edinburgh Genomics

• Provides advanced genomic services using the latest technologies
• End to end support from extracted nucleic acids to data analysis
• Bioinformatics expertise to ensure high quality sequencing data generation